Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 − the “plunger” − pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex − the “barrel” − into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the “barrel” is an ATP-independent process, whereas extraction (...) of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model. The peroxin PEX5 is the peroxisomal matrix protein receptor. It shuttles between the cytosol and the organelle membrane, where it gets inserted into the docking/translocation module, thus pushing the cargo-protein into the peroxisome lumen. Resetting the system involves PEX5 monoubiquitination and its extraction from the membrane by the AAA-ATPases, PEX1/PEX6. (shrink)

As inúmeras tentativas de verificação do quinto postulado de Euclides geralmente culminavam com matemáticos receosos diante do mundo novo com que se deparavam em suas provas incompletas. Seria apenas com a concepção de que o postulado das paralelas é um caso extremo de deformação do espaço que o enigma encontraria uma solução. Assim como a geometria hiperbólica recorre a um espaço tridimensional para definir a geometria plana como um fenômeno característico da superfície de uma esfera com raio infinito, a hipótese (...) deste trabalho é executar uma operação lógica semelhante à Ética de Spinoza ao testarmos a elasticidade do experimento mental do escólio da proposição 44 da segunda parte. A metafísica hiperbólica com que nos deparamos é a das infinitas séries de tempo de Jorge Luis Borges. (shrink)

In spite of his deep insights, Hegel fails to grasp the specific character of the war waged by the French Revolution and the Empire. His theory of limited warfare turns out to be a peculiar Sollen, but it is precisely this gap between rationality and reality what makes his classical model an appealing antithesis to postmodern violence. Keywords.

A theory can be an explanation of a piece of the world. A theory of law is intended to be an explanation of that phenomenon of social communication which we call Law. But, Raffaele De Giorgi, perhaps the person responsible for the introduction of luhmannian theory in Argentina, (jointly with Torres Nafarrate in Mexico in translating Luhmann’s work to Spanish), asked: What is a theory of society? What is the “Law of society”? And answered: Can we discuss this?, hands managed (...) by hands, nothing different from a prostheses. According to De Giorgi we are sure that the themes that we use as objects or objects that we use as themes, are our construction, we think that we turn around ourselves, while we continue rotating around the vacuum. It is a paradox, or another paradox: ¿Is it possible to get out or get rid of these paradoxes? Logic does not help us. Logic, according to Luhmann, can only see to the fact that some expressions, with unavailable truths, are in contradiction with other expressions, the problem cannot be resolved us- ing logical operations. With the help of Gegenparadoxierungen (against-par- adox), systemic therapy is the alternative where the problem can be toler- ated. And, according to Luhmann, the placement of the paradox should be conducted in a more or less skilled, successful, or useful way to break the logjam.A creative use of paradoxes, especially legal ones, allows us to observe how Luhmann’s theory has impacted existing theories in ArgentinaThemes such as the paradoxality of law, or its being without foundation (and without beginning, the vacuity of their principles and the opacity of its distinctions and operations), filtered theories (like Carlos Cárcova or Ernesto Grün) and jurisprudential practices have started shifting things to what Bielefeld Professor has called “old European”Resumen:Una teoría puede ser una explicación de un sector del mundo. Una teoría del derecho pretende ser una explicación de ese fenómeno de comunicación social que llamamos derecho. Pero, Raffaele De Giorgi, tal vez uno de los máximos responsables de la introducción de la teoría de la luhmanniana en la Argentina (junto a Javier Torres Nafarrate de México, a través de su traducción de las obras de Luhmann al español), pregunta:¿Qué es una teoría de la sociedad? ¿Qué es el “Derecho de la sociedad”? y responde: es que podemos discutir esto?, manos que son manejadas por manos, nada diferente de una prótesis. Y agrega: estamos seguros de que los temas que usamos como objetos o los objetos que utilizamos como temas, son nuestra construcción, pensamos que nos volvemos sobre nosotros mismos, mientras continuamos girando alrededor del vacío.Es una paradoja, u otra paradoja. ¿Es posible salir, deshacerse de estas paradojas? La lógica no nos ayuda. La lógica dice Luhmann, sólo puede ver el hecho de que algunas expresiones, cuya verdad no está disponible, entran en contradicción con otras expresiones, para las cuales vale decir la misma cosa. Usando operaciones lógicas, el problema no puede ser resuelto. Como terapia sistémica la única que podemos ver, con el auxilio de la Gegenparadoxierungen (“contra-paradoja”), es un lugar menos doloroso en el que puede tolerarse el problema. Y recordó que, en cierto sentido, la colocación de la paradoja se realizará con más o menos éxito, esto es: de manera útil para desbloquear la situación.Y es el uso creativo de paradojas, especialmente uno que se hizo por el Derecho, el que nos permite observar cómo su teoría (la de Luhmann) se ha comenzado a reciclar en las teorías existentes en Argentina. Temas como el problema de la paradojalidad del Derecho, de su ser sin fundamentos y sin comienzo, de la vacuidad de sus principios y la opacidad de sus operaciones y distinciones, se filtran teorías (como las de Carlos Cárcova o Ernesto Grün) y prácticas de la jurisprudencia y puede verse que ha comenzado a remover ese tipo de pensamiento que el profesor de Bielefeld había llamado “vétero europeo”. (shrink)

Osteopathy is a person-centred healthcare discipline that emphasizes the body’s structure-function interrelationship—and its self-regulatory mechanisms—to inform a whole-person approach to health and wellbeing. This paper aims to provide a theoretical framework for developing an integrative hypothesis in osteopathy, which is based on the enactivist and active inference accounts. We propose that osteopathic care can be reconceptualised under active inference as a unifying framework. Active inference suggests that action-perception cycles operate to minimize uncertainty and optimize an individual’s internal model of the (...) lived world and, crucially, the consequences of their behaviour. We argue that active inference offers an integrative framework for osteopathy, which can evince the mechanisms underlying dyadic and triadic exchanges and osteopathic care outcomes. We propose that this theoretical framework can underpin osteopathic care across the lifespan, from preterm infants to the elderly and those with persistent pain and other physical symptoms. In situations of chronicity, as an ecological niche, the patient-practitioner dyad provides the osteopath and the patient with a set of affordances, i.e., possibilities for action provided by the environment, that through shared intentionally, can promote adaptations and restoration of productive agency. Through a dyadic therapeutic relationship, as they engage with their ecological niche’s affordances—a structured set of affordances shared by agents—osteopath and patient actively construct a shared sense-making narrative and realise a shared generative model of their relation to the niche. In general, touch plays a critical role in developing a robust therapeutic alliance, mental state alignment, and biobehavioural synchrony between patient and practitioner. However, its role is particularly crucial in the fields of neonatology and paediatrics, where it becomes central in regulating allostasis and restoring homeostasis. We argue that from an active inference standpoint, the dyadic shared ecological niche underwrites a robust therapeutic alliance, which is crucial to the effectiveness of osteopathic care. Considerations and implications of this model—to clinical practice and research, both within- and outside osteopathy—are critically discussed. (shrink)

Este artículo cuestiona filosóficamente, a partir de las tesis de Günther Anders, el uso masivo de las redes sociales y la forma en que configuran la subjetividad y la intersubjetividad, particularmente en cuanto a los efectos cognitivos sobre la verdad, las creencias y la objetividad. El uso intensivo y compulsivo de las redes sociales ha permitido una comunicación casi instantánea y una sociedad presta a la observación y vigilancia de todos los aspectos de la vida cotidiana y de la política; (...) pero, al mismo tiempo, ha impulsado una sociedad de la intrusión, el voyerismo, el juicio moral lapidario y el linchamiento público de personajes famosos o de cualquier persona acosada por sus conductas, aunque estas pudieran no ser verdaderas. Manuel Castells observaba en La era de la información (2000), que en nuestra época se ha trastocado el tiempo, se han fundido y confundido lo real y lo virtual, lo público y lo privado, generando nuevos problemas éticos, jurídicos y políticos. Tenemos ahora una subjetividad hipersensibilizada, saturada de información, de verdades y falsedades indistinguibles que complican la comunicación y el sentido compartido de la realidad, así como las responsabilidades y las acciones sociales efectivas para contribuir al bien público. (shrink)

Se busca rastrear la imagen que Platón tiene de Heráclito y articularla con la estructura argumentativa del Cratilo, para comprender las necesidades textuales a las que responde la doctrina del flujo perpetuo, es decir, la discusión sobre la corrección (ὀρθότης) del nombre. Gracias a la inclusión del testimonio heraclíteo, resulta posible rastrear la presunta consolidación de la tesis sobre los nombres primarios y los secundarios como el eje de la separación entre dos planos de realidad (uno estable y uno móvil) (...) y de la teoría de las Ideas -es decir, como la base de la epistemología platónica presente en los diálogos de madurez-. The article seeks to trace the image Plato has of Heraclitus and connect it with the argumentative structure of the Cratylus in order to understand the textual needs that give rise to the doctrine of perpetual flux, that is, the discussion regarding the correctness (ὀρθότης) of names. The inclusion of Heraclitus's testimony makes it possible to trace the alleged consolidation of the thesis regarding primary and secondary names as the axis of separation between two levels of reality (one stable, the other, changing) and the theory of Ideas -that is, as the basis of Plato's epistemology as set forth in the late dialogues-. (shrink)

RESUMENLas nanotecnologías constituyen actualmente elsector másinnovador y desafiante en el desarrollo tecnocientífico-industrial. Dado que nuestrastecnociencias no son capaces de crearsistemas que sean tanto o más consistentes, más estables y autosustentables que los sistemas naturales, son necesarias e indispensables la supervisión y la regulación prudencial y precautoria de sus efectos y consecuencias, esperadas e inesperadas, mediante un debate público con amplia participación democrática. La nanoética es una forma de poner en acción una racionalidad colectiva prudencial que, en vistas del alcance omniabarcador (...) de las nanotecnologías, tiene que ser construida a partir de principios éticos de alcance global y debe tener un carácter prospectivo.PALABRAS CLAVENANOTECNOLOGÍA, REGULACIÓN, RIESGO TECNOLÓGICO, NANOÉTICAABSTRACTNowadays nanotechnologies constitute the most innovative and challenging sector in technoscientific-industrial development. Our technosciences aren’t capable of generating equally or more consistent stable and self-sufficient systems than natural systems. Therefore, supervision together with reasonable and precautionary regulation of their effects and consequences -being these expected or unexpected-, in the form of public debate with ample democratic participation proves to be necessary. Nanoethics is a way of starting a reasonable collective rationality movement which, in view of the all-containing span of nanotechnologies, must be constructed from ethic principles that have a global reach and must as well have a prospective character.KEYWORDSNANOTECHNOLOGY, REGULATION, TECHNOLOGICAL RISK, NANOETHICS. (shrink)

ResumenEl estudio de las prácticas materiales de una sociedad requiere considerar los tipos de enmarcamiento epistemológico en que se desarrollan y sus efectos sobre éstas. Los modos de categorizar y distinguir y los modos organizar y agrupar son parte del enmarcamiento de las prácticas que este texto aborda. En particular, explora conceptualmente los modos de organización de conjuntos basados en la distinción agregativa entre lo singular y lo plural y los modos de organización enfocados en el efecto compositivo de la (...) diferencia entre molécula y masa. El ejercicio conceptual propone que ambos modos de organización sean empleados en conjunto, habilitando describir fenómenos de agregación y composición integrados sincrónica y diacrónicamente en la organización material de lo social.Palabras clave: agregación; composición; distinción; organización; prácticas materiales. (shrink)

In 1968, Aimé Césaire travelled to Cuba to participate in the Havana Cultural Congress, a mass international meeting where delegates discussed the place of culture in the struggle against imperialism, neo-colonialism, and underdevelopment. Among the likes of C.L.R. James, Nicolás Guillén, René Depestre, Michel Leiris, and Daniel Guérin, it was in Havana that the Martinican politician undertook the until-now untranslated interview with Sonia Aratán for the Casa de las Américas revue and delivered his Cultural Congress conference paper – previously believed (...) by Césaire scholars to be lost. Both texts shed light on Césaire’s little-known views on Fidel Castro, the Cuban Revolution and Marxism in the context of late-1960s tricontinentalism. By reconstructing Césaire’s exchanges with Cuban writers before and during the Congress, we propose a consideration of the role of Cuba in Césaire’s political thought as a tragic possibility, combining the catastrophe of Caribbean history with the uncertain potential of new social forms. (shrink)

This paper offers theoretical explanations for why “guided touch” or manual touch with verbal communication can be an effective way of treating the body and the mind. The active inference theory suggests that chronic pain and emotional disorders can be attributed to distorted and exaggerated patterns of interoceptive and proprioceptive inference. We propose that the nature of active inference is abductive. As such, to rectify aberrant active inference processes, we should change the “Rule” of abduction, or the “prior beliefs” entailed (...) by a patient’s generative model. This means pre-existing generative models should be replaced with new models. To facilitate such replacement—or updating—the present treatment proposes that we should weaken prior beliefs, especially the one at the top level of hierarchical generative models, thereby altering the sense of agency, and redeploying attention. Then, a new prior belief can be installed through inner communication along with manual touch. The present paper proposes several hypotheses for possible experimental studies. If touch with verbal guidance is proven to be effective, this would demonstrate the relevance of active inference and the implicit prediction model at a behavioral level. Furthermore, it would open new possibilities of employing inner communication interventions, including self-talk training, for a wide range of psychological and physical therapies. (shrink)

1. El proceso de Atenas -- 2. El proceso de Jerusalem.

Recognizing and aligning individuals’ unique adaptive beliefs or “priors” through cooperative communication is critical to establishing a therapeutic relationship and alliance. Using active inference, we present an empirical integrative account of the biobehavioral mechanisms that underwrite therapeutic relationships. A significant mode of establishing cooperative alliances—and potential synchrony relationships—is through ostensive cues generated by repetitive coupling during dynamic touch. Established models speak to the unique role of affectionate touch in developing communication, interpersonal interactions, and a wide variety of therapeutic benefits for (...) patients of all ages; both neurophysiologically and behaviorally. The purpose of this article is to argue for the importance of therapeutic touch in establishing a therapeutic alliance and, ultimately, synchrony between practitioner and patient. We briefly overview the importance and role of therapeutic alliance in prosocial and clinical interactions. We then discuss how cooperative communication and mental state alignment—in intentional communication—are accomplished using active inference. We argue that alignment through active inference facilitates synchrony and communication. The ensuing account is extended to include the role of tactile afferents in realizing the beneficial effect of therapeutic synchrony. We conclude by proposing a method for synchronizing the effects of touch using the concept of active inference. (shrink)

El presente texto nace del proyecto de investigación en gestión empresarial que se adelanta en el programa de administración de empresas donde están vinculados los autores. Se presenta la persecución del éxito empresarial y la ética sindical como la finalidad de consolidar el desarrollo sustentable latinoamericano. En ese sentido las nuevas realidades laborales se han estado enfocando recientemente en la productividad, en la eliminación del trabajo estático dando lugar al trabajo remoto y la formación de equipos de trabajo sinérgicos, que (...) respondan a las inclinaciones de esta nueva descendencia de subalternos, afectando así a las organizaciones sindicales que dependen del claustro de trabajo. (shrink)

This comprehensive reference volume features essays by some of the most distinguished scholars in the field. Provides a comprehensive "who's who" guide to medieval philosophers. Offers a refreshing mix of essays providing historical context followed by 140 alphabetically arranged entries on individual thinkers. Constitutes an extensively cross-referenced and indexed source. Written by a distinguished cast of philosophers. Spans the history of medieval philosophy from the fourth century AD to the fifteenth century.

A first-of-its-kind book that seriously and profoundly examines what it means philosophically to be Latino and where Latinos fit in American society. Offers a fresh perspective and clearer understanding of Latin American thought and culture, rejecting answers based on stereotypes and fear Takes an interdisciplinary approach to the philosophical, social, and political elements of Hispanic/Latino identity, touching upon anthropology, history, cultural studies and sociology, as well as philosophy Written by Jorge J. E. Gracia, one of the most influential thinkers (...) of Hispanic/Latino descent. (shrink)

And how are the answers to these questions affected by the Black and Latino experience in the United States"-From the Preface This collection of new essays explores the relation between race and ethnicity and its social and political ...

Although most predicates may be truthfully predicated of only some beings, there are others that seem to apply to every being. The latter, including being itself, were known as the transcendentals in the Middle Ages and gave rise to the much disputed doctrine of the transcendentals. This article explores the main tenets of the doctrine and the difficulties that they face, the reasons why scholastic authors were interested in these issues, and the origins of the doctrine.

This volume provides a superb introduction to the philosophical, social, and political elements of Hispanic/Latino identity. It is an indispensable tool for anyone interested in issues that concern Hispanics/Latinos, social policy, and the history of thought and culture.

IF THE HISTORY OF PHILOSOPHY studies ideas from the past, as is generally accepted, then historians of philosophy face a serious problem concerning their object of study for two reasons. In the first place, like all history, the history of philosophy is concerned with the past and we can never have direct empirical access to the past unless that past is close to us and we have taken part in it. In order to know the past in which we have (...) not participated we must rely on the testimony of those who had direct access to it and left records of what they witnessed. In the second place, the problem arises because the specific object that the history of philosophy studies is ideas and ideas are not things, events, or facts for which we can have direct empirical evidence even if we are contemporaneous with them. The most we can have is indirect empirical evidence. We do not perceive ideas; what we perceive are certain phenomena that suggest to us certain ideas. If I ask you, for example, "Do you approve of what the President did?" and you frown in return, I conclude that you do not. But it is altogether possible that you do in fact approve of the President's action, although you wish me to think that you do not and thus mislead me by making the frown. My conclusion that you do not, then, can be taken only as an interpretation of what you are thinking based on certain empirical evidence that is only indirectly related to what you think. Thus the study of the history of philosophy is very difficult, more difficult than the study of the type of history that relies on events for which there can be direct empirical evidence; for not only is direct access to the past impossible for historians of philosophy from the present, but even if they had it they would not have direct access to the ideas which are supposed to be the object of their study. (shrink)

The author begins by distinguishing six fundamental issues on the metaphysics of individuality.

Twenty-two leading Latin American philosophers are featured in this complete anthology on the human condition, values, and the search for identity. Bibliography.

The concept of shared mental models refers to the shared understanding among team members about how they should behave in different situations. This article aimed to develop a new shared mental model measure, specifically designed for the refereeing context. A cross-sectional study was conducted with three samples: national and regional football referees (n = 133), national football referees and assistant referees and national futsal referees (n = 277), and national futsal referees (n = 60). The proposed version of the Referee (...) Shared Mental Models Measure (RSMMM) has 13 items that are reflected on a single factor structure. The RSMMM presented good validity evidence both based on the internal structure and based on relations to other variables (presenting positive associations with team work engagement, team adaptive performance, and team effectiveness). Such promising psychometric properties point to an optimistic outlook regarding its use to measure shared mental models in futsal and football referee teams. -/- . (shrink)

__Forging People __explores the way in which Hispanic American thinkers in Latin America and Latino/a philosophers in the United States have posed and thought about questions of race, ethnicity, and nationality, and how they have interpreted the most significant racial and ethnic labels used in Hispanic America in connection with issues of rights, nationalism, power, and identity. Following the first introductory chapter, each of the essays addresses one or more influential thinkers, ranging from Bartolomé de Las Casas on race and (...) the rights of Amerindians; to Simon Bolívar's struggle with questions of how to forge a nation from disparate populations; to modern and contemporary thinkers on issues of race, unity, assimilation, and diversity. Each essay carefully and clearly presents the views of key authors in their historical and philosophical context and provides brief biographical sketches and reading lists, as aids to students and other readers. “Latin American philosophy has a long history of engagement with issues of race, ethnicity, and nationality. To date, however, there has been no volume that focused on the contributions of the major figures in the Latin American tradition, to illustrate their connections, and to illuminate the context in which much of their work occurred. This volume fills that gap and takes an important step in remedying this shortcoming in the existing philosophical literature, and also in the literature of related fields such as Latin American studies, ethnic studies, and the cross-disciplinary work of race, ethnicity, and nationality.” —_Manuel Vargas, University of San Francisco _. (shrink)